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Coenzyme Q-10 Benefits, Sources, Dosage And Deficiency
Coenzyme Q10 is a potent, naturally occurring vitamin-like compound, encouraging chemical reactions, protecting the body from free radicals, playing a key role in the production of energy, in every cell of the body. It assists circulation, strengthens the immune system, boosts tissue oxygenation and has vital anti-aging effects. Deficiencies of coenzyme Q10 have been correlated to various diseases such as periodontal disease, diabetes and muscular dystrophy, among others.
What Is Coenzyme Q10?
Coenzyme Q10 or Ubiquinone, a powerful antioxidant, existing in most eukaryotic cells, especially in the mitochondria, is an oil-soluble substance, similar to a vitamin, found in every cell of the body, in highest potency on vital organs like kidney, liver, brain and heart.
Food Sources Of Coenzyme Q10
Fish sources of CoenzymeQ10 include Salmon, tuna, sardines and Mackerel. Meat sources are Eggs, Liver, lamb, pork and beef along with Organ meats such as Beef liver, heart and muscle. Other sources include Chicken heart, Pork liver, heart and muscle.
Fruit sources of CoQ10 include Apple, orange, grapefruit, avocado, strawberry and black currant. Vegetables sources of CoQ10 are Cauliflower, broccoli, parsley, Chinese cabbage and spinach. Nuts and seeds high in CoQ10 are Peanuts, walnuts, pistachios, almonds, hazelnuts and sesame seeds
Functions Of Coenzyme Q10
Initial studies indicated that low levels of Co Q10 in the blood might be one of the causes for hypertension. However, consumption of CoQ10 along with blood pressure medicines helped maintain healthy blood pressure levels.
Source : http://www.pharmaceutical-networking.com/merck-mk-0524b-treatment-of-atherosclerosis/
Due to its potent antioxidant properties, CoQ10 inhibit coagulation of the arteries, thereby protecting against atherosclerosis
Low levels of CoQ10 in the blood increase cholesterol levels in the body. However, CoQ10 supplements help maintain healthy cholesterol levels by reducing the LDL cholesterol and increasing the HDL cholesterol.
Congestive Heart Failure
CoQ10 reduced symptoms of Congestive heart failure like insomnia, exhaustion and shortness of breath.
Research reveals that administering CoQ10 to patients prior to heart surgery helps cut down the free radicals in the body with a significant drop in arrhythmias and angina.
There have been contradictory opinions regarding the efficacy of CoQ10 on Diabetes. However, few scientists point out that CoQ10 apart from combating oxidative stress also helped with better glycemic control in patients suffering from this disorder
One of the major contributors towards carcinogenesis is considered the Reactive oxygen species (ROS) that cause significant DNA damage. Studies reveal a correlation between advanced stages of cancer and low levels of CoQ10. Therefore, besides regular medication and treatment, prescribing antioxidants such as omega3 and 6 fatty acids, in conjunction with CoQ10, might be beneficial for patients suffering from advanced breast cancer.
Due to the antioxidant action, CoQ10 prevents the incidence of infections. Therefore, it is highly effective for people suffering from this syndrome.
Source : http://www.parkinsondisease.in/
Certain Researches points out that initial stages of Parkinson Disease treated with CoQ10 may gradually prolong cognitive deterioration symptoms of the disease.
CoQ10 helps prolong the process of dementia in people with Alzheimer’s disease by promoting cognitive thinking and performance.
One of the key reasons for male infertility is low levels of CoQ10 leading to oxidation, often resulting in depleted mobility of sperm. Studies prove that regular consumption of CoQ10 apart from promoting immunity also enhances the density and mobility of sperm in men with infertility.
Studies reveal that women taking CoQ10 supplements from the 20th week of pregnancy until delivery had reduced chances of developing pre-eclampsia.
The main cause for asthma is known to be the cause of oxygen free radicals along with inadequate antioxidants in the body. Nevertheless, administering antioxidants with CoQ10 supplements besides reducing oxidative stress also helps decrease symptoms of asthma.
CoQ10 also helps prevent migraine.
CoQ10 helped improve muscle strength and physical functioning in people suffering from a genetically inherited disorder called muscle dystrophy.
CoQ10 facilitates production of energy transferring molecules called Adenosine triphosphate (ATP). Therefore, to improve the production of extra bouts of energy and strength on muscle tissues, CoQ10 supplements would be highly beneficial.
Source : http://www.perio.org/consumer/2a.html
One of the main causes of gum disease known as periodontitis, with symptoms of plaque and bad breath, is due to low levels of CoQ10 in the gums. Therefore, CoQ10 supplement apart from providing the required energy to fight bacteria also help cure gum disease.
After a particular age, the body loses its ability to produce CoQ10 leading to age related problems and low energy levels resulting in a decline of antioxidant actions. However, with the use of beauty products containing CoQ10, the process of aging, along with fine lines and wrinkles can be treated, besides protecting the skin from the harmful rays of the sun.
CoQ10 has the ability to stop hair loss caused by anticoagulants such as warfarin.
Daily requirement of CoQ10
Adults (above 18 years of age)
For adults above 18 years of age, the requirement is 30 to 90 mg in 2 or 3 separate doses.
Adults (without deficiencies)
For adults without deficiencies the dosage is 10 to 30 mg of CoQ10 supplement in a single dose. It is not advisable for children below 18 years of age and pregnant women. However, it would be wise to seek the advice of a medical expert for the required dosage, before taking the supplements.
Deficiency Symptoms of CoQ10
The deficiency symptoms of CoQ10 occur gradually over a period of time and at most times these symptoms get neglected. These include cardiac problems such as MVP (mitral valve prolapse), hypertension, irregular heart beat, breathlesness and cardiomyopathy. Other symptoms include exhaustion, weight gain, muscle weakness and pain in the joints
Deficiency of CoenzymeQ10
A potent antioxidant existing in every cell of the body, low levels of CoQ10 may lead to innumerable deficiency symptoms. Since CoQ10 in conjunction with mitochondrial cells, produce a spurt of energy by converting food into energy, low levels of the enzymes lead to persistent mental and physical fatigue along with pain and weakness in the muscles
Another sign of CoQ10 deficiency is an increased risk of diabetes. A supplement combined with a healthy lifestyle, can help conquer this disorder. Lack of this enzyme may lead to Parkinson’s and Alzheimer’s disease. Low levels of the enzyme may cause hardening of the arteries with increased blood pressure and cholesterol levels leading to arrhythmias, angina and cardiac failure.
Overdose and Side effects of CoQ10
Despite being safe with no serious side effects, there are some evidences of mild side effects of this enzyme. However, it is not advisable for children below 18 years of age and pregnant women. There is also a possibility of CoQ10 interference with a patient’s blood pressure control, during and after surgery. Hence, it is advisable to stop taking CoQ10 two week prior to the surgery.
Since there are chances of CoQ10 increasing the effects of Blood Pressure medications, with an abnormal drop in Blood pressure levels. Besides these there are other side effects such as diarrhoea, vomiting, nausea, loss of appetite, stomach upset, heart burn, headache, skin itching and rashes along with symptoms associated to flu. In addition, a few studies opine that there are possibilities of CoQ10 interfering with a man’s sperm count. CoQ10 should be used with utmost care since they tend to lower sugar levels in Diabetics.
According to reports, CoQ10 taken with Anticoagulants such as clopidigrel and warfarin become ineffective.
Blood pressure medications
There may be a requirement to adjust the dosage of blood pressure medications when taken with CoQ10, as beta-blockers such as propranolol, metoprolol, labetolol and atenolol, tend to lower levels of CoQ10.
Statins and fibric acid derivatives, prescribed to maintain healthy Cholesterol levels too have a tendency to lower levels of CoQ10.
Antidepressants such as imipramine, doxepin and amitriptyline lower levels of CoQ10 in the body.Coenzyme Q-10 Benefits, Sources, Dosage And Deficiency,